THE IMPACT OF RETROACTIVITY ON THE BEHAVIOR OF BIO-MOLECULAR SYSTEMS A Review of Recent Results
نویسنده
چکیده
Modularity is a powerful property for analyzing the behavior of a system on the basis of the behavior of its components. According to this property, any two components maintain their behavior unchanged upon interconnection. Is modularity a natural property of bio-molecular networks? In this review, we summarize recent theoretical and experimental results that demonstrate that the answer to this question is negative. Just as in many electrical, mechanical, and hydraulic systems, impedance-like effects, called retroactivity, arise at the interconnection of bio-molecular systems and alter the behavior of connected components. Here, we illustrate the effects of retroactivity on the static characteristics and on the dynamic input/output response of bio-molecular systems by employing a mixture of control theoretic tools, mathematical biology, and experimental techniques on reconstituted systems.
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